BioPorto Diagnostic

AntibodyShop

Anti-Peptide YY (human, PYY)

Mouse monoclonal antibody

Cat.No. ABS 029-01

Subclass IgG1/k

Presentation:

Preparation: Protein-A purified
Content: Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
Solvent: 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Storage: 4-8ºC without exposure to light. No precautions necessary during handling.

Antigen:

Peptide tyrosine-tyrosine (PYY) amide is a 36 amino acid. PYY is a member of the pancreatic polypeptide (PP) family of peptides (neuropeptide Y (NPY), PYY and PP). While NPY is localized in neurons (both in the central and peripheral nervous system) and PP in the pancreatic islets, PYY is found in both neurons and the gut. PYY is released in response to food intake from the same endocrine cells (L cells) in the intestinal mucosa as the glucagon-like peptides and inhibits gall bladder secretion, gut motility, and pancreatic secretion. These effects are similar to those of PP and overlap with the gut inhibitory activity of GLP-1.

Immunogen:

Synthetic human PYY adsorbed onto aluminum hydroxide gel

Specificity:

ABS 029-01 binds human PYY. Cross-reactivity with NPY or PP in solution is <0.1%.

Epitope specificity:

Not determined

Reactivity:

ABS 029-01 binds free PYY in solution.

ABS 029-01 reacts in ELISA with PYY coated directly onto the microtiter well. Biotinylated ABS 029-01can be used as detection antibody with ABS 051-04 as capture antibody for measuring PYY(3-36) by sandwich ELISA.

Application: