Anti-Complement component C1 inhibitor (human, C1INH)
Mouse monoclonal antibody
Cat.No. HYB 288-05
Preparation: Protein-A/G purified
Content: Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
Solvent: 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Storage: 4-8ºC without exposure to light. No precautions necessary during handling.
C1-inhibitor (C1INH) functions as a regulator of the activation of the classical complement pathway and of the contact activation system of kinin generation and coagulation. Its primary biologically relevant target proteinases are C1r, C1s, coagulation factors XIa and XIIa, and plasma kallikrein. C1-inhibitor consists of one polypeptide chain and has a molecular mass of 104 kDa (1,2). Serum concentration has been determined to 180 µg/ml (2).
C1-inhibitor (C1INH) isolated from human plasma adsorbed onto aluminum hydroxide gel
HYB 288-05 is specific for human C1INH
Epitope specificity differs from that of HYB 288-02
HYB 288-05 reacts strongly with C1-INH. A strong reaction is seen with human serum/plasma when tested in sandwich ELISA in combination with a polyclonal antibody against C1-INH, and in ELISA with C1-INH coated directly onto the microtiter well.
| Method | Usability | References |
| ELISA | Yes | |
| Immunoblotting | Not determined | |
| Immunohistochemistry | Not determined |
1. Law SKA, Reid KBM (1988) Complement. In: In Focus (Ed. Male D) IRL Press: Oxford.
2. Rasmussen JM (1991) Inherited deficiencies of complement proteins with special reference to congenital deficiency of the regulatory protein factor I. APMIS Suppl 22:1-48.
3. Bendtzen K et al (2000) Basal og klinisk immunologi. FADL´s Forlag A/S, Copenhagen.
4. Bracho FA (2005) Heriditary angioedema. Curr Opin Hematol Nov12(6):493-98
Downloads
HYB 288-05.pdf (30.09 kB) Product specification
ELISA Kits and Monoclonal antibodies for the Complement system - flyer.pdf (637.76 kB) ELISA Kits and Monoclonal antibodies for the Complement system
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